Niyanta Kumar

Company: Mersana Therapeutics

Job title: Associate Director

Seminars:

Leveraging PBPK Modeling to Predict the Clinical Impact of DDI and Organ Impairment for ADCs 2:00 pm

Case study describing a PBPK modeling and simulation approach to predict the impact of drug-drug interactions (DDI) and hepatic impairment on clinical PK of an ADC with an auristatin-based payload (auristatin F-hydroxypropylamide [AF-HPA]) Model development and verification using a combination of in vitro, pre-clinical, and clinical ADME/PK data using mixed ‘bottom-up’ and ‘top-down’ approaches Overview…Read more

day: Conference Day 2