Optimizing the Bioanalysis Strategy for ADCs – Developing Robust Bioanalytical Approaches for ADC Characterization
Time: 9:00 am
day: Pre-Conference Day
Details:
Join this workshop to gain insights into the latest bioanalytical strategies and techniques driving the development and evaluation of antibody-drug conjugates. Explore challenges and best practices in ADC characterization, quantification, and biomarker assessment, and learn how to translate bioanalytical findings into actionable insights for ADC clinical development.
• Utilizing cutting-edge analytical techniques to assess ADC structural integrity, drug-to-antibody ratio (DAR), and conjugation site occupancy
• Implementing in-vivo bioanalysis tools to better predict ADC behaviour
• Navigating challenges in ADC quantification and Pharmacokinetic assessment
• Addressing complexities in quantifying ADCs and their metabolites in biological matrices
• Strategies for overcoming matrix effects, stability challenges, and assay interference in ADC bioanalysis
• Interpreting bioanalytical data to guide ADC optimization, dosing regimen selection, and patient stratification strategies
• Leveraging biomarkers and pharmacodynamic endpoints to elucidate ADC mechanism of action and predict clinical outcomes
• Exploring innovative approaches for evaluating target engagement, payload release, and downstream signaling effects of ADCs
