More Than the Sum of Their Parts: Integrating Data & Knowledge of ADCs in a QSP Platform Model to Predict Efficacy and Toxicity In the Clinic
Time: 9:30 am
day: Conference Day 1
Details:
- Implementation of a next generation platform systems pharmacology model for preclinical to clinical translation of ADC efficacy, clinical dose predictions including outcome (RECIST) criteria and differentiation from SoC in different oncology indications
- Development of a mechanistic model for prediction of ADC induced haematological toxicities and use to predict optimal dose and regimen to avoid thrombocytopenia
