Dosing for Novel Conjugates: Defining the Key Characteristics of an “Ideal” Therapeutic Payload & Understanding Novel PK Properties
Time: 1:30 pm - 4:30 pm
day: Pre-Conference Workshop Day
Details:
This session will delve into the challenges and opportunities of dosing next generation ADCs. From dissecting unique PK behaviors of novel payloads to integrating preclinical data into first-in-human dose predictions, we’ll explore how to design smarter, safer, and more effective ADCs. Get practical strategies, emerging science, and translational perspectives that tackle the evolving complexity of ADC design and clinical development.
- Understand how novel payload properties influence ADC clearance, distribution, and safety beyond the antibody component
- Examine how molecular complexity impacts stability, bioanalysis, and dose optimization in the clinic
- Evaluate and manage the clinical implications of payload characteristics and potential drug interactions
- Improve dose prediction confidence by addressing disconnects between early assessments and clinical reality
- Better predict and monitor novel ADC behavior in patients through integrating imaging, biomarker, and advanced analytical strategies
