Pre-Conference Workshop Day
8:30 am Check-In & Light Refreshments
Morning Workshop
9:30 am Investigating the Effects on Modelling & Dosing when expanding into ADC Combinations
Synopsis
Join this workshop to explore how next generation dosing strategies can unlock the full potential of ADC combination therapies. There is no silver bullet for treatment, and combinations are widely considered the next step in oncology treatment, so in this workshop you’ll dive into the latest thinking, tools, and translational tactics that are reshaping combination regimens. Gain practical insights and forward-looking perspectives to help bring more potent, precise, and patient-centered ADC combinations to the clinic.
- Driving smarter ADC combination designs with preclinical data and clinical signals
- Fine-tune exposure, manage additive toxicities, and amplify efficacy with brand-new strategies
- Predicting the best dose, schedule, and combination partner for your ADC using PK/PD modelling
- Personalized combination regimens for different tumor types and patient populations
- Tackling drug-drug interactions, shifting PK profiles, and translational disconnects
- Building clinical protocols that balance benefit and risk in first-in-combo trials
12:30 pm Lunch Break & Networking
Afternoon Workshop
1:30 pm Dosing for Novel Conjugates: Establishing FIH Dose Prediction Using Preclinical Insights & Understanding Novel PK Properties
Synopsis
This session will delve into the challenges and opportunities of dosing next generation ADCs. From dissecting unique PK behaviors of novel payloads to integrating preclinical data into first-in-human dose predictions, we’ll explore how to design smarter, safer, and more effective ADCs. Get practical strategies, emerging science, and translational perspectives that tackle the evolving complexity of ADC design and clinical development.
- Understand how novel payload properties influence ADC clearance, distribution, and safety beyond the antibody component
- Examine how molecular complexity impacts stability, bioanalysis, and dose optimization in the clinic
- Evaluate and manage the clinical implications of payload characteristics and potential drug interactions
- Improve dose prediction confidence by addressing disconnects between early assessments and clinical reality
- Better predict and monitor novel ADC behavior in patients through integrating imaging, biomarker, and advanced analytical strategies